如何探寻靶向或结合蛋白质的小分子

如何探寻靶向或结合蛋白质的小分子

How to explore small molecules targeting or binding with proteins

        内源或外源小分子常通过靶向或结合蛋白质发挥作用。因此，探寻靶向或结合蛋白质的小分子对于机制研究十分重要。本文将讲解如何挖掘靶向或结合蛋白质的小分子。

Endogenous or exogenous‌ small molecules usually exert effects by targeting or binding with proteins. Therefore, exploration of small molecules targeting or binding with proteins is crucial for mechanical study. This article shows how to dig small molecules targeting or binding with proteins.

利用NCBI- PubChem BioAssay挖掘靶向或结合蛋白质的小分子，步骤如下：

NCBI-PubChem BioAssay could be used to dig small molecules targeting or binding with proteins, and steps are as follows:

1 从https://www.ncbi.nlm.nih.gov/网址进入NCBI

1 Enter NCBI from https://www.ncbi.nlm.nih.gov/

2 点击“Resource List (A-Z)”，选择“PubChem BioAssay”

2 Click “Resource List (A-Z)”，select “PubChem BioAssay”

3 输入蛋白质名称（AKT1），选择“"AKT1"[Protein Target Name]”，搜索

3 Input the protein name (AKT1)，select “"AKT1"[Protein Target Name]”, search

4 查看结果

4 View results

5 点击项目（2）查看详情

5 Click item (2) to view details

另外，还可以利用BioGRID挖掘靶向或结合蛋白质的小分子，步骤如下：

Additionally, BioGRID also could be used to dig small molecules targeting or binding with proteins, and steps are as follows:

1 从https://thebiogrid.org/网址进入BioGRID

1 Enter BioGRID from https://thebiogrid.org/

2 输入蛋白质名称（AKT1），选择物种（人类），搜索

2 Input the protein name (AKT1)，select an organism (Homo sapiens), search

3 查看结果

3 View results